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PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Affiliation:1. Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;2. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;3. Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;4. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;5. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;6. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;7. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;8. Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA;9. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;10. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;11. Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;12. University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany;13. Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
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  • Keywords:stem cells  metabolism  cardiac maturation  fatty acid oxidation  PPAR signaling
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