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Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria
Institution:1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA;2. Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK;3. Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA;4. Bioinformatics and Computational Bioscience Branch, NIAID, NIH, Bethesda, MD 20892, USA;5. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA;6. Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, NIAID, NIH, Bethesda, MD 20892, USA;7. Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD 20892, USA;8. NIAID Microbiome Program, NIAID, NIH, Bethesda, MD 20892, USA
Abstract:
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  • Keywords:invasive candidiasis  antibiotics  vancomycin  lymphocytes  IL-17A  GM-CSF  trans-kingdom infections
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