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Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine
Institution:1. Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA;2. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;3. Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan;4. Department of Bioengineering, University of California, San Diego, San Diego, CA 92093, USA;5. Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;6. F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;7. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;8. Division of Pediatric Infectious Diseases, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;9. Division of Infectious Diseases, Rady Children’s Hospital, San Diego, CA 92123, USA
Abstract:
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  • Keywords:vaccine  IsdB  antibody  vaccine failure  original antigenic sin  antibody competition  immunization
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