A fluorinated vitamin D3 analog with biopotency greater than 1 alpha, 25-dihydroxy vitamin D3期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A fluorinated vitamin D3 analog with biopotency greater than 1 alpha, 25-dihydroxy vitamin D3

Authors:	R A Corradino H F DeLuca Y Tanaka N Ikekawa Y Kobayashi

Affiliation:	1. Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706 USA.;2. Laboratory for Chemistry and Natural Products, Tokyo Institute of Technology, Tokyo, Japan.;3. Tokyo College of Pharmacy, Tokyo, Japan.

Abstract:	Vitamin D metabolites and analogs induce $de novo$ synthesis of a specific calcium-binding protein in embryonic chick duodenum maintained in organ culture. Using calcium-binding protein biosynthesis as a specific and sensitive biochemical indicator of intrinsic biopotency, 24,24-difluoro-1α,25-dihydroxy vitamin D₃ was found to be approximately four times more potent on a molar basis than the most active, naturally occurring metabolite, 1α,25-dihydroxy vitamin D₃.

Keywords:	To whom correspondence should be addressed: Department of Physical Biology and Section of Physiology New York State College of Veterinary Medicine Cornell University Ithaca NY 14853.
本文献已被 ScienceDirect PubMed 等数据库收录！