Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities |
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| Authors: | Jahng Yurngdong Zhao Long-Xuan Moon Yoon-Soo Basnet Arjun Kim Eun-kyung Chang Hyeun Wook Ju Hye Kyung Jeong Tae Cheon Lee Eung-Seok |
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| Institution: | College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea. |
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| Abstract: | For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity. |
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