Somatostatin is a potent activator of phosphoprotein phosphatases in the digestisve tract

This study demonstrates that somatostatin is a potent (K_d = 0.5 · 10^?11 M) and apparently selective activator of phosphoprotein phosphatase activity in homogenates and cytosolic extracts prepared from liver and pancreas, as well as from gastric and intestinal epithelial cells. It is suggested that protein dephosphorylation could account for at least some of the physiological effects of the tetradecapeptide in the digestive tract.