Dexamethasone effects on liver pyruvate kinase |
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Authors: | Mark L. Johnson Joell B. Hansen James C. Donofrio Carlo M. Veneziale |
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Affiliation: | Department of Cell Biology, Mayo Medical School, Rochester, MN 55901, U.S.A. |
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Abstract: | Dexamethasone in the medium perfusin isolated rabbit livers caused a fast-acting and reversible effect on liver pyruvate kinase. The effect was to lower th assayable V activity (units/g tissue) without changing the concentration (nmol/g enzyme protein). In effect, glucocorticoid lowered the specific activity (units/nmol of enzyme) by direct action on liver. The effect on liver pyruvate kinase is mediated by a relatively stable alteration; 30 min after perfusate (with steroid) was replaced by perfusate (without steroid), the effect remained strongly evident. |
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Keywords: | Pyruvate kinase Dexamethasone (Rabbit liver) |
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