Lead effect on the oxidation resistance of erythrocyte membrane in rat triton-induced hyperlipidemia |
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Authors: | L Zimmermann N Pages H Antebi A Hafi C Boudene L G Alcindor |
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Institution: | (1) Department of Biochemistry, Faculty of Medicine Paris-Ouest, UFR des Saints Pères, 45 rue des Saints Pères, 75006 Paris;(2) Laboratory of Toxicology, Faculty of Pharmacy, 5 rue Jean Baptiste Clément, 92296 Chatenay Malabry, France |
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Abstract: | The anemia observed in severe chronic lead poisoning is in part attributable to alterations in the erythrocyte physicochemical
properties. Since they are partly related to the membrane lipid composition, the aim of the present study was to determine
the effects of a triton-induced hyperlipidemia on the resistance to oxidation of erythrocyte membranes in lead-treated Wistar
rats.
Our results showed that triton administration to lead-treated rats induced an increase in erythrocyte choline phospholipid
levels together with a significant decrease in the erythrocyte membrane lipid resistance to oxidation. These results led us
to suggest that anemia in lead poisoning is linked to interactions between lead present in the membrane and plasma phospholipids.
Their increase in rat hyperlipidemia induced by triton resulted in a decrease in the membrane resistance to oxidation and
finally in an erythrocyte fragility leading to their destruction. |
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Keywords: | Triton-induced hyperlipidemia lead-treated rat erythrocyte membrane lipid peroxidation |
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