Changing spatial patterns of DNA replication in the developing wing of Drosophila |
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| Authors: | M Schubiger J Palka |
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| Institution: | 1. Biochemistry & Molecular Biology Program, Departments of Biology and Chemistry, The College of Wooster, Wooster, OH, United States;2. Department of Microbiology & Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States;1. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA;1. Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China;2. Surgery Research Center, School of Medicine, Southeast University, Nanjing, China;3. State Education Ministry Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing, China;1. Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest, Hungary;2. “Momentum” Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest 1094, Hungary;3. Department of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest 1122, Hungary |
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| Abstract: | Using an antibody against bromodeoxyuridine we have analyzed the distribution of S-phase nuclei in the wing disc of Drosophila as the larval disc transforms into the adult wing during metamorphosis. On the basis of the timing of replication three cell populations can be distinguished: the cells of the presumptive wing margin, the precursor cells of the longitudinal veins, and those of the intervein regions. In each of these populations the cell cycle is first arrested and later resumes at a specific time, so that at each developmental time point a characteristic spatial pattern of S-phase nuclei is seen. An interpretation of these changing patterns in terms of vein formation, compartments, and neural development is offered. |
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