Cardiotoxin of the Indian cobra(Naja naja) is a pyrophosphatase |
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Authors: | K E Achyuthan L K Ramachandran |
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Institution: | (1) Department of Biochemistry, Osmania University, 500 007 Hyderabad |
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Abstract: | An inorganic pyrophosphatase has been purified to apparent homogeniety from Indian cobra(Naja naja) venom, with a ten-fold increase in specific activity. The enzyme activity is intrinsic to a protein fraction in the venom
which is normally termed cardiotoxin, cobramine, cytotoxin and so on. The enzyme shows a lowK
m (70 μI) and high heat stability. The enzyme was active against sodium pyrophosphate; it also hydrolyses a few mononucletides
and sugar phosphates at much lower rates. The physiological significance of inorganic pyrophosphatase in venom is discussed. |
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Keywords: | Cobra venom Naja naja cardiotoxin pyrophosphatase |
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