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The proteolytic activity of human prostate-specific antigen |
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| Authors: | Y Ban M C Wang K W Watt R Loor T M Chu |
| Affiliation: | 1. Department of Diagnostic Immunology Research and Biochemistry, Roswell Park Memorial Institute, Buffalo, New York 14263 USA;2. Cetus Corporation, Emeryville, California 94608 USA |
| Abstract: | Human prostate-specific antigen has been found to exhibit a mild activity of protease at neutral pH. This finding is based on two observations: a proteolytic activity was always associated with the antigen fractions during purification, and the proteolytic activity and the antigen were precipitated with specific antibody to the antigen. In comparison with physico-chemical and catalytic properties of known proteases, human prostate-specific antigen is a distinct neutral protease. |
| Keywords: | PA prostate-specific antigen Me-casein N,N-dimethylcasein ATEE N-acetyl-L-tyrosine ethyl ester BAEE N-benzoyl-L-arginine ethyl ester BTEE N-benzoyl-L-tyrosine ethyl ester BANA α-N-benzoyl-DL-arginine-β-napthylamide BAPNA α-N-benzoyl-DL-arginine-p-nitroanilide LNA L-leucine-β-naphthylamide PMSF phenylmethylsulfonyl fluoride TLCK N-α-p-tosyl-L-lysine chloromethyl ketone TPCK L-1-tosylamide-2-phenylethylchloromethyl ketone |
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