绣球菌降血糖作用及活性成分分析

绣球菌是一种珍稀食药用真菌,本文对其醇提取物的降血糖作用及活性成分进行了研究.高脂高糖饲料联合链脲佐菌素造模建立了 Ⅱ型糖尿病小鼠模型,设置空白对照组、模型组、绣球菌提取物高、中、低3个剂量组(300、200和100mg/kg),连续给予相应药物3周,对各组小鼠的体重、血糖、血脂和胰腺进行组织病理学研究.结果显示:与模...

Hypoglycemic effect and compositional analysis of active compounds of Sparassis latifolia

Hypoglycemic effect and active compounds in ethanolic extract of Sparassis latifolia fruiting bodies are investigated.TypeⅡdiabetes mellitus mouse model induced by combined administration of streptozotocin and high-sugar feed was adopted.Normal control,diabetic model control,three groups treated with different dosages of the fungal extract(300,200 and100 mg/kg)and positive control were designed.Oral administration of the fungal extract was conducted daily for three weeks.Body weight,blood glucose,lipid levels and histopathological change of pancreas of the tested mice were investigated.Compared with the diabetic control group,the levels of blood glucose and cholesterol of mice treated with S.latifolia extract were significantly reduced.The protective effects were further supported by the histopathological observation of pancreas that the shape,amount,distribution ofβcells were obvious ameliorated The active compounds of S.latifolia extract were analyzed by UPLC-Triple-TOF/MS.Ten compounds were identified,and several of them might be involved in glucose and fat metabolism.The results may supply theoretical and technical support for the application and development of S.latifolia.