Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase |
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| Authors: | Adisakwattana Sirichai Ngamrojanavanich Nattaya Kalampakorn Kanyarat Tiravanit Wilaiwon Roengsumran Sophon Yibchok-Anun Sirintorn |
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| Institution: | Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. |
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| Abstract: | Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 microM +/- 0.24 microM, compared with the IC50 value of voglibose (IC50 = 23.4 +/- 0.30 microM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a Ki value in the range of 1.31-1.56 x 10(-5)M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor. |
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