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Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production |
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| Authors: | Elisabetta Carata Clelia Peano Salvatore M Tredici Francesco Ferrari Adelfia Talà Giorgio Corti Silvio Bicciato Gianluca De Bellis Pietro Alifano |
| Affiliation: | (1) Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy;(2) Institute for Biomedical Technologies, National Research Council, 20090 Segrate, Milan, Italy;(3) Department of Biology, University of Padova, 35121 Padova, Italy;(4) Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy |
| Abstract: | BackgroundThere is evidence from previous works that bacterial secondary metabolism may be stimulated by genetic manipulation of RNA polymerase (RNAP). In this study we have used rifampicin selection as a strategy to genetically improve the erythromycin producer Saccharopolyspora erythraea. |
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