DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks |
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| Authors: | Wanda M Waterworth Jaroslav Kozak Claire M Provost Clifford M Bray Karel J Angelis and Christopher E West |
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| Institution: | (1) CPS, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK;(2) Institute of Experimental Botany AS CR, Na Karlovce 1, 160 00 Praha 6, Czech Republic;(3) Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK |
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| Abstract: | Background DNA ligase enzymes catalyse the joining of adjacent polynucleotides and as such play important roles in DNA replication and
repair pathways. Eukaryotes possess multiple DNA ligases with distinct roles in DNA metabolism, with clear differences in
the functions of DNA ligase orthologues between animals, yeast and plants. DNA ligase 1, present in all eukaryotes, plays
critical roles in both DNA repair and replication and is indispensable for cell viability. |
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