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Proteomics studies confirm the presence of alternative protein isoforms on a large scale |
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| Authors: | Michael L Tress Bernd Bodenmiller Ruedi Aebersold |
| Affiliation: | (1) Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, Madrid, 28029, Spain;(2) Institute of Molecular Systems Biology, ETH, Wolfgang-Pauli-Str., 8093 Zurich, Switzerland;(3) Institute for Systems Biology, Seattle, WA 98103, USA;(4) Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, 8093 Zurich, Switzerland;(5) Faculty of Science, University of Zurich, 8057 Zurich, Switzerland |
| Abstract: | BackgroundAlternative splicing of messenger RNA permits the formation of a wide range of mature RNA transcripts and has the potential to generate a diverse spectrum of functional proteins. Although there is extensive evidence for large scale alternative splicing at the transcript level, there have been no comparable studies demonstrating the existence of alternatively spliced protein isoforms. |
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