| 恶性淋巴瘤患者及一级亲属染色体脆性部位的研究 |
| |
| 引用本文： | 孙 慧,李 伟 刘全章 孙艳阳 王恒湘,宋 岩 李 璞 SUN Hui,LI Wei,LIU Quan-Zhang,SUN Yan-Yang,WANG Heng-Xiang,SONG Yan LI Pu.恶性淋巴瘤患者及一级亲属染色体脆性部位的研究[J].遗传,1994,16(4):5-8. |
| |
| 作者姓名： | 孙 慧 李 伟 刘全章 孙艳阳 王恒湘 宋 岩 李 璞 SUN Hui LI Wei LIU Quan-Zhang SUN Yan-Yang WANG Heng-Xiang SONG Yan LI Pu |
| |
| 作者单位： | （1山东省泰山医学院生物教研室， 泰安 271000；2 哈尔滨医科大学生物教研室， 哈尔滨 150086 1 Biology department, Taishan Medical College,Taian Shangdong 271000;2.Biology department,harbin medical university, Harbin 271000 ） |
| |
| 摘 要： | 本文对24例恶性淋巴瘤患者和20例患者的一级亲属染色体脆性部位进行了观察，发现两组的脆性部位表达率均高于正常对照，并且脆性部位3 14、11 13、6 22和12 13表达显著增高。提示这些特异的脆性部位可能与恶性淋巴瘤遗传易感性有关。Abstract:The Chromsomal aberration rate and expression frequency of common fragile sites were examined in peripheral blood lymphocyted with TC199 medium from 24 patients with malignant lymphoma and 20 of their first-degree relatives. Both the chromosomal aberration rates and expression frequencies of fragile sites obscrved in patient and their relatives were significantly higher than those of control subjects, especially the expression of fra(3)(p14), fra(11)(p22) and fra(12)(q13) which migh be affected by some genetic factors and might play an important role in genetic susceptibility to malignant lymphoma.
|
| 关 键 词： | Malignant lymphomas 遗传易感性 Key words 脆性部位 恶性淋巴瘤 关键词 细胞系 G-显带 人体乳腺癌 |
The Study of Chromosomal Fragile in Patients with Malignant Lymphomas and Their First-degree Relatives |
| |
| SUN Hui,LI Wei,LIU Quan-Zhang,SUN Yan-Yang,WANG Heng-Xiang,SONG Yan,LI Pu.The Study of Chromosomal Fragile in Patients with Malignant Lymphomas and Their First-degree Relatives[J].Hereditas,1994,16(4):5-8. |
| |
| Authors: | SUN Hui LI Wei LIU Quan-Zhang SUN Yan-Yang WANG Heng-Xiang SONG Yan LI Pu |
| |
| Abstract: | |
| |
| Keywords: | Human breast cancer Cell line Chromosome G-banding |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
| 点击此处可从《遗传》下载免费的PDF全文 |
|
