小鼠异常行为及其继代遗传特性

实验室条件下小鼠常表现多种异常行为,通过对跳跃爬行鼠和非跳跃爬行鼠的亲代及F1代的行为观察,研究小鼠异常行为在继代过程中的变化规律以及皮质醇浓度与异常行为的关系。结果表明:两代跳跃爬行鼠和非跳跃爬行鼠的异常行为差异显著(P<0.05),在正常行为中跳跃爬行鼠的平均睡眠时间和修饰行为的次数明显少于非跳跃爬行鼠(P<0.05),而探究行为的次数明显高于非跳跃爬行鼠(P<0.05)。F1代跳跃爬行鼠的异常行为类型基本和母体一致,异常行为的发生次数明显高于亲代,说明异常行为具有遗传基础。通过测定皮质醇浓度,发现跳跃爬行鼠的皮质醇平均浓度明显高于非跳跃爬行鼠(P<0.05),说明皮质醇的分泌量影响着异常行为的发生频率。

The aberrant behaviour and inheritance of continued generations in mice

The mice had lots of aberrant behaviour in lab conditions.The behaviour of the thely-mice were observed of the jumping mice and non-jumping mice of F1 and parential generations.Regularity of the social behaviour and the relationship of the concentration of the corticosteroid and the aberrant behaviour of mice in continued generations were also studied.The results indicated that aberrant behaviour was significant difference between the jumping mice and the non-jumping mice(P<0.05).The hours of sleeping were significantly longer for the non-jumping mice than those in the jumping mice(P<0.05).The frequency of decorating behaviour for the non-jumping mice was significantly more than that in the jumping mice(P<0.05).The frequency of searching behaviour for the jumping mice was significantly more than the non-jumping mice(P<0.05).The types of the aberrant behaviour of the jumping mice of F1 were the similar to those of the parential generation.The concentration of corticosteroid of the jumping mice was higher than that of the non-jumping mice(P<0.05).The results suggested that the secretory of corticosteroid influenced the frequency of the aberrant behaviour of mice.