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The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function |
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| Authors: | Jacqueline Hayles David Beach Barbara Durkacz Paul Nurse |
| Affiliation: | (1) School of Biological Sciences, University of Sussex, Falmer, BN1 9QG Brighton, East Sussex, UK;(2) Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A 3PX London, UK;(3) Present address: Cold Spring Harbor Laboratory, P.O. Box 100, 11724 Cold Spring Harbor, NY, USA;(4) Present address: Cancer Research Unit, Royal Victoria Infirmary, Queen Victoria Road, NE1 4LP Newcastle-upon-Tyne, UK |
| Abstract: | Summary A DNA fragment called suc1 has been found to rescue cells mutated in the cell cycle control gene cdc2 of the fission yeast Schizosaccharomyces pombe. The suppressing activity of suc1 is observed when it is present on a multicopy number plasmid. The gene does not hybridise to cdc2 and maps elsewhere in the genome. Its effect is cdc2 allele specific suggesting that it interacts directly with the cdc2 gene function. |
| Keywords: | Yeast Cell cycle Extragenic suppressors |
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