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Transient permeability induced by alkyl derivatives of amphotericin B in lipid membranes |
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| Authors: | Vafa Ibragimova Khalil Kasumov |
| Institution: | a Department of Biophysics, Baku State University, Z. Khalilov str., 23 AZ-1148 Baku, Azerbaijan b Laboratory of Molecular Biophysics, Baku State University, Z. Khalilov str., 23 AZ-1148 Baku, Azerbaijan c Institute of Botany Academy of Sciences Azerbaijan Republic and Department of Molecular Biology Azerbaijan State Academy of Physical Culture and Sport, Baku, Azerbaijan, F. Khoyski ave. 98, AZ-1072 Baku, Azerbaijan d Larial Proteomics Inc., Medical and Related Science Centre, South Tower, 101 College str., room 350, Toronto, ON, Canada M5G 1L7 |
| Abstract: | Individual ionic channels were shown to be formed in the brain cholesterol containing phospholipid membranes by two-sided addition of the amphotericin B alkyl derivatives. At concentrations between 10−8 and 10−7 M, the resulting conductance appeared to be transient. Existence of different antibiotic assemblies was justified by the kinetic analysis of the membrane conductance decline following the antibiotic washing out. In order to account for the transient characteristics of the induced conductance, it was proposed that the antibiotic oligomers incorporate into the membrane from the aqueous phase, form channels aggregating with cholesterol, and then dissociate in the bilayer into non-active degraded oligomeric or monomeric forms. |
| Keywords: | Amphotericin B Alkyl derivatives of amphotericin B Transient permeability in membrane The kinetic of the membrane conductance Washing out the antibiotic Dissociate Non active monomeric form |
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