| 见血封喉乳汁中具有细胞毒活性的强心苷 |
| |
| 引用本文： | 阙东枚,梅文莉,干玉娟,曾艳波,戴好富. 见血封喉乳汁中具有细胞毒活性的强心苷[J]. 热带亚热带植物学报, 2010, 18(4): 440-444. DOI: 10.3969/j.issn.1005-3395.2010.04.019 |
| |
| 作者姓名： | 阙东枚 梅文莉 干玉娟 曾艳波 戴好富 |
| |
| 作者单位： | 中国热带农业科学院热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海口,571101 |
| |
| 基金项目： | 国家自然科学基金项目，中央级公益性科研院所基本科研业务费专项资金 |
| |
| 摘 要： | 从见血封喉(Antiaris toxicaria (Pers.) Lesch.)乳汁分离得到4个强心苷类化合物，经波谱数据分析，分别鉴定为：毒毛旋花子爪哇糖苷(1)、铃兰毒苷(2)、毒毛旋花子阿洛糖苷(3)和glucostrophanthidin (4)。化合物4为首次从见血封喉中分离得到。细胞毒活性测定结果表明，化合物1~4对慢性髓原白血病细胞(K562)、人胃癌细胞(SGC-7901)和人肝癌细胞(SMMC-7721)的增殖均显示了较强的生长抑制活性。
|
| 关 键 词： | 见血封喉 乳汁 强心苷 细胞毒活性 |
| 收稿时间： | 2009-10-28 |
| 修稿时间： | 2010-02-07 |
Cytotoxic Cardenolides from the Latex of Antiaris toxicaria |
| |
| QUE Dong-mei,MEI Wen-li,GAN Yu-juan,ZENG Yan-bo and DAI Hao-fu. Cytotoxic Cardenolides from the Latex of Antiaris toxicaria[J]. Journal of Tropical and Subtropical Botany, 2010, 18(4): 440-444. DOI: 10.3969/j.issn.1005-3395.2010.04.019 |
| |
| Authors: | QUE Dong-mei MEI Wen-li GAN Yu-juan ZENG Yan-bo DAI Hao-fu |
| |
| Affiliation: | Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences,Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences,Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences,(Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences,Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences |
| |
| Abstract: | Four cardenolides were obtained from the latex of Antiaris toxicaria (Pers.) Lesch. On the basis of spectral data, they were identified as strophanthojavoside (1), convallatoxin (2), strophalloside (3), and glucostrophanthidin (4). Compound 4 was isolated from Antiaris toxicaria for the first time. Compounds 1~4 showed significant inhibitory activity towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines. |
| |
| Keywords: | Antiaris toxicaria Latex Cardenolides Cytotoxicity |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《热带亚热带植物学报》浏览原始摘要信息 |
|
点击此处可从《热带亚热带植物学报》下载全文 |
|
