Phorbol ester contracts rabbit thoracic aorta by increasing intracellular calcium and by activating calcium influx |
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| Authors: | M M Gleason S F Flaim |
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| Institution: | 1. School of Hotel and Tourism Management The Hong Kong Polytechnic University, 17 Science Museum Road TST East, Kowloon, Hong Kong, China;2. Department of Hospitality, Hotel Management and Tourism Texas A&M University 600 John Kimbrough Boulevard 2261 TAMU College Station, TX, USA, 77843;1. Department of Ecology & Evolutionary Biology, University of Toronto, 25 Willcocks Street, Room 3055, Toronto, Ontario, Canada, M5S 3B2;2. Moore Institute for Plastic Pollution Research, 160 N. Marina Dr, Long Beach, CA, 90803, United States;3. Environmental Services Department, Orange County Sanitation District, 10844 Ellis Ave, Fountain Valley, CA, 92708, United States;4. Department of Fisheries, Wildlife, and Conservation Sciences, Coastal Oregon Marine Experiment Station, Oregon State University, 2030 SE Marine Sciences Drive, Newport, OR, 97365, United States;5. Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Biologische Anstalt Helgoland, Helgoland, Germany;6. Thermo Fisher Scientific, 5225-1 Verona Rd, Fitchburg, WI, 53711, United States;7. Oak Ridge Institute of Science Education, c/o U.S. Environmental Protection Agency, ORD/CEMM Atlantic Coastal Environmental Sciences Division, 27 Tarzwell Drive, Narragansett, RI, 02882, United States;8. Barnett Technical Services, LLC 8153 Elk Grove Blvd., Suite 20 Elk Grove, CA 95758, United States;9. Lever Photonics, Broomfield, CO, USA;10. RJ Lee Group, 350 Hochberg Road, Monroeville, PA 15146, United States;11. Institute for Nanotechnology and Correlative Microscopy - INAM, Äußere Nürnbergerstr. 62, 91301 Forchheim, Germany;12. HORIBA Scientific, 20 Knightsbridge Rd, Piscataway, NJ 08854, United States;13. Norwegian Institute for Water Research, Oslo, Norway, Department of Biological Sciences, Univeristy of Bergen, Bergen, Norway;14. HORIBA Instruments Inc., 430 Indio Ave, Sunnyvale, CA, 94085, United States;15. Southern California Coastal Water Research Project Authority, 3535 Harbor Blvd., Suite 110, Costa Mesa, CA 92626, USA;p. Eastman Chemical Company, 100 N. Eastman Rd., Kingsport, TN, 37660, United States;q. Fraunhofer Institute for Ceramics Technology and Systems - IKTS, Äußere Nürnbergerstr. 62, 91301 Forchheim, Germany;1. Farmer School of Business, Miami University, 800 E. High Street, Oxford, OH, United States;1. Department of Marketing, Farmer School of Business, Miami University, United States;2. Department of Business Administration, University of Illinois at Urbana-Champaign, United States;3. Department of Marketing, Kelley School of Business, Indiana University, United States;1. School of Economics and Management, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China;2. School of Hotel and Tourism Management, The Hong Kong Polytechnic University, 17 Science Museum Road, TST East, Kowloon, Hong Kong SAR;3. School of Tourism and Hotel Management, Dongbei University of Finance & Economics, 217 Jianshan Street, Dalian 116025, China;4. The School of Hospitality Business, Michigan State University, 667 N. Shaw Lane, East Lansing 48824, MI, USA |
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| Abstract: | The ability of the phorbol ester tumor promoter, PDB, to activate contraction and stimulate calcium influx was investigated in rabbit thoracic aorta. PDB caused a strong, slowly-developing sustained contraction in physiological salt solution which was concentration-related (0.01 to 10.0 microM). PDB-induced contractions (0.1 microM) in calcium-free medium were attenuated but not prevented. PDB (1.0 microM) maximally stimulated Ca influx above basal control, vehicle = 39.2 +/- 2.2; PDB 1.0 microM = 70.7 +/- 6.7 mumoles Ca/kg tissue; N = 16, p less than 0.01). These data suggest that PDB activates rabbit thoracic aorta by a combination of intracellular and extracellular calcium dependent mechanisms. |
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