Entamoeba histolytica: Diffuse Liver Inflammation in Gerbils (Meriones unguiculatus) with Experimentally Induced Amebic Liver Abscess |
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Authors: | K CHADEE E MEEROVITCH |
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Institution: | Institute of Parasitology of McGill University, Macdonald College, 21,111 Lakeshore Road, Ste.-Anne de Bellevue, Québec, H9X ICO, Canada |
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Abstract: | The histopathological changes that occur in the uninfected liver lobes of gerbils with a localized amebic liver abscess (left lobe) were studied from 5 to 60 days after inoculation. Early parenchymal changes (10 days) in the right and median liver lobes showed a lymphocytic infiltrate and bile duct proliferation in the portal areas. Maximum alternations occurred at 20 to 30 days after inoculation and were characterized by a dense portal infiltrate, hepatocyte degeneration, granulocytic infiltrate and marked glycogen depletion. In drug-treated infections with metronidazole, the diffuse liver inflammation was terminated. The results of this study suggest that the diffuse liver injury was directly or indirectly induced by the presence of a proliferating amebic liver abscess and that the pathology caused by amebic liver abscess is more extensive than previously thought. |
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Keywords: | Bile duct proliferation histopathologykw lymphocytic infiltration metronidazole |
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