| Institution: | a Laboratório de Imunomodulação e Protozoologia do Instituto Oswaldo Cruz/FIOCRUZ, Pavilhão Carlos Chagas, 3° andar, Av. Brasil, 4365, Manguinhos, CEP 20045-900, Rio de Janeiro, Brazil
b Departamento de Patologia, Universidade Estadual do Maranhão, Cidade Universitária Paulo VI, S/N, Tirirical, CEP 65054-970, São Luís, Maranhão, Brazil |
| Abstract: | We infected Swiss and C57BL/6 female mice in the left hind footpad with 104Leishmania (L.) amazonensis promastigotes in stationary phase. The macroscopic examination showed a nodular non-ulcerated lesion at the site of inoculation and hepatic and spleenic enlargement. Histopathologically, the primary lesion showed an extensive liquefactive necrosis and inflammatory infiltrate, mainly consisting of macrophages filled with amastigotes, and rare lymphocytes. The inflammatory reaction in liver, spleen and kidney showed amyloid deposits. Additionally, C57BL/6 had accentuated amyloidosis in both ovarian cortical and medullar region and inflammatory infiltrates in the pancreas and adrenal gland. |
