Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice |
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| Authors: | Anne-Katja Imhof Laura Glück Mieczyslaw Gajda Rolf Bräuer Hans-Georg Schaible Stefan Schulz |
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| Institution: | 1.Institute of Pharmacology and Toxicology,University Hospital, Friedrich Schiller University,Jena,Germany;2.Institute of Pathology,University Hospital, Friedrich Schiller University,Jena,Germany;3.Institute of Physiology I,University Hospital, Friedrich Schiller University,Jena,Germany |
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| Abstract: | Introduction Endothelins are involved in tissue inflammation, pain, edema and cell migration. Our genome-wide microarray analysis revealed
that endothelin-1 (ET-1) and endothelin-2 (ET-2) showed a marked up-regulation in dorsal root ganglia during the acute phase
of arthritis. We therefore examined the effects of endothelin receptor antagonists on the development of arthritis and inflammatory
pain in monoarthritic mice. |
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