Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation |
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Authors: | Guillen C Bartolomé A Nevado C Benito M |
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Institution: | a Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain b CIBER de Diabetes y Enfermedades Metabólicas Asociadas, ISCIII, Spain |
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Abstract: | Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high levels of circulating insulin may contribute to beta cell damage. To address this important issue, we submitted beta cells to a prolonged effect of increasing concentrations of insulin. We observed that a prolonged effect of high levels of insulin on the presence of serum (15-24 h) in glucose-deprived beta cells induced apoptosis. This apoptotic effect was both dose- and cycloheximide-dependent. |
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Keywords: | Beta cell Insulin Glucose deprivation Apoptosis |
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