Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization |
| |
| Authors: | Jing Chen Liang Zhang Yu Zhang Haitao Zhang Jiamu Du Jianping Ding Yuewei Guo Hualiang Jiang and Xu Shen |
| |
| Institution: | (1) Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China;(2) Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, PR China |
| |
| Abstract: | Background The natural product Emodin demonstrates a wide range of pharmacological properties including anticancer, anti-inflammatory,
antiproliferation, vasorelaxant and anti-H. pylori activities. Although its H. pylori inhibition was discovered, no acting target information against Emodin has been revealed to date. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
