多囊卵巢综合征肥胖患者血清维生素D、铁蛋白水平、sICAM-1与胰岛素抵抗、糖脂代谢指标的相关性

摘要 目的：探讨多囊卵巢综合征（PCOS）肥胖患者血清维生素D、铁蛋白、可溶性细胞间粘附分子-1（sICAM-1）水平与胰岛素抵抗、糖脂代谢指标的相关性。方法：2018年8月到2021年11月，选择在本院妇科诊治的PCOS患者65例作为研究对象，分为PCOS肥胖组（n=30，体重指数＜28 kg/m²）和PCOS非肥胖组（n=35，体重指数<28 kg/m²）。检测与计算两组清维生素D、铁蛋白、sICAM-1、胰岛素抵抗、糖脂代谢指标并进行相关性分析。结果：两组的血清甲状腺素（T4）、促甲状腺激素（TSH）与泌乳素（PRL）对比差异无统计学意义（P>0.05），肥胖组的血清促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮（T）水平高于非肥胖组（P<0.05）。肥胖组的血清铁蛋白、sICAM-1水平高于非肥胖组，血清维生素D水平低于非肥胖组（P<0.05）。肥胖组的胰岛素抵抗指数（HOMA-IR）、胰岛素水平（FINS）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）较非肥胖组，高密度脂蛋白胆固醇（HDL-C）低于非肥胖组（P<0.05）。在PCOS肥胖患者中，Pearson分析显示血清维生素D、铁蛋白、sICAM-1与胰岛素抵抗、糖脂代谢指标都存在相关性（P<0.05）。结论：PCOS肥胖患者与非肥胖患者的血清维生素D、铁蛋白、sICAM-1、胰岛素抵抗、糖脂代谢指标水平存在差异，血清维生素D、铁蛋白、sICAM-1水平与胰岛素抵抗、糖脂代谢指标存在相关性。

Correlation of Serum vitamin D, Ferritin levels, sICAM-1 with Insulin Resistance, Glucose and Lipid Metabolism Indexes in Obese Patients with Polycystic Ovary Syndrome

ABSTRACT Objective: To investigate the relationship between serum vitamin D, ferritin, and sICAM-1 levels in obese patients , who has polycystic ovary syndrome and insulin resistance, glucose and lipid metabolism indexes sex. Methods: From August 2018 to November 2021, 65 PCOS patients diagnosed and treated in the department of gynecology in our hospital were selected as the research objects, and they were divided into polycystic ovary syndrome obesity group (n=30, body mass index 28 kg/m²) and multiple Cystic ovarian syndrome non-obese group (n=35, body mass index <28 kg/m²). Detect and calculate the two groups of vitamin D, ferritin, sICAM-1, insulin resistance, glucose and lipid metabolism indicators and conduct correlation analysis. Results: There were no difference in serum T4, TSH and PRL between the two groups (P>0.05). The serum luteinizing hormone in the obese group The levels of LH, FSH and T were higher than those in the non-obese group (P<0.05). The levels of serum ferritin and sICAM-1 in the obese group were higher than those in the non-obese group, and the serum vitamin D levels were lower than those in the non-obese group (P<0.05). Insulin resistance index (HOMA-IR), insulin level (FINS), TG, TC and LDL-C in obese group were higher than those in non-obese group, while high density lipoprotein cholesterol (HDL-C) was lower than those in non-obese group (P<0.05). In obese patients with polycystic ovary syndrome, Pearson analysis showed that serum vitamin D, ferritin, sicAM-1 were correlated with insulin resistance and glucolipid metabolism (P<0.05). Conclusion: The polycystic ovary syndrome obese patients and non-obese patients Serum vitamin D, ferritin, sICAM-1, insulin resistance, glucose and lipid metabolism index levels are different, and serum vitamin D, ferritin, sICAM-1 levels are correlated with insulin resistance and glucose and lipid metabolism indexes.