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Aurora-A激酶对急性胰腺炎大鼠肺脏损伤的修复作用研究
引用本文:解凤妮,李云龙,岳 蓉,李彩茹,文 雯,闫黎娜,周晓燕. Aurora-A激酶对急性胰腺炎大鼠肺脏损伤的修复作用研究[J]. 现代生物医学进展, 2021, 0(18): 3422-3425
作者姓名:解凤妮  李云龙  岳 蓉  李彩茹  文 雯  闫黎娜  周晓燕
作者单位:空军医科大学第一附属医院消化监护室 陕西 西安 710032;西安大兴医院急诊科 陕西 西安710016;陕西中医药大学第二附属医院新生儿科 陕西 咸阳 712000;陕西中医药大学附属医院肿瘤二科 陕西 咸阳 712000
基金项目:陕西省中医管理局中医药科研项目(JCPT004)
摘    要:摘要 目的:探讨与研究Aurora-A激酶对急性胰腺炎大鼠肺脏损伤的修复作用。方法:36只雄性SD大鼠均分为三组:对照组、模型组与Aurora-A组。对照组进行假手术操作,模型组建立急性胰腺炎模型后给予注射等量生理盐水治疗,Aurora-A组建立急性胰腺炎模型后给予阴茎背静脉注射鼠Aurora-A类因子-MLN8054 10 mg/kg治疗,记录大鼠肺脏损伤的修复情况。结果:造模过程中无大鼠死亡情况发生,模型组与Aurora-A组造模后2 w与4 w的肺组织病理评分、血清中性粒细胞弹性蛋白酶(neutrophil elastase,NE)与髓过氧化物酶(myeloperoxidase,MPO)含量、肺组织W/D、肺组织蛋白激酶B(AKT)、细胞外信号调节激酶1(ERK1)蛋白相对表达水平都高于对照组(P<0.05),Aurora-A组少于模型组(P<0.05)。结论:Aurora-A激酶在急性胰腺炎大鼠的应用能抑制Akt/ERK信号通路激活,减少血清NE与MPO的表达,从而促进肺脏损伤修复。

关 键 词:Aurora-A激酶;急性胰腺炎;肺脏损伤;髓过氧化物酶;细胞外信号调节激酶1
收稿时间:2021-01-27
修稿时间:2021-02-23

Study on the Repairing Effect of Aurora-A Kinase on Lung Injury in Rats with Acute Pancreatitis
Abstract:ABSTRACT Objective: To explore and study the repair effect of Aurora-A kinase on lung injury in rats with acute pancreatitis. Methods: 36 cases of male SD rats were equally divided into three groups-control group, model group and Aurora-A group. The control group were given underwent sham operation, the model group were treated with the same amount of normal saline after the acute pancreatitis model were established, and the Aurora-A group were treated with the mouse Aurora-A factor-MLN8054 10 mg/kg after the acute pancreatitis model were established. Recorded the repair effects of rat lung injury. Results: There were no rats died during the modeling process. The lung tissue pathology scores, serum neutrophil elastase (NE) and myeloperoxidase(MPO), lung tissue W/D, lung tissue protein kinase B (AKT), and extracellular signal-regulated kinase 1 (ERK1) protein in the model group and Aurora-A group at 2 weeks and 4 weeks after modeling were higher than those in the control group(P<0.05), the Aurora -A group were less than the model group (P<0.05). Conclusion: The application of Aurora-A kinase in acute pancreatitis rats can inhibit the activation of Akt/ERK signaling pathway, reduce the expression of serum NE and MPO, and promote lung injury repair.
Keywords:Aurora-A kinase   Acute pancreatitis   Lung injury   Myeloperoxidase   Extracellular signal-regulated kinase 1
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