热毒宁注射液联合更昔洛韦注射液对呼吸道合胞病毒感染肺炎患儿血清炎症因子和T细胞亚群的影响

摘要 目的：观察热毒宁注射液联合更昔洛韦注射液对呼吸道合胞病毒（RSV）感染肺炎患儿血清炎症因子和T细胞亚群的影响。方法：60例RSV感染肺炎患儿均来自我院2017年1月-2020年12月期间收集的病例，依据随机数字表法分为对照组和研究组，各30例。对照组患儿接受更昔洛韦注射液治疗，研究组患儿接受热毒宁注射液联合更昔洛韦注射液治疗，均治疗7d。对比两组患儿疗效、血清炎症因子、T细胞亚群、症状缓解时间和不良反应。结果：研究组的总有效率为93.33%，高于对照组的66.67%（P<0.05）。治疗后，研究组降钙素原（PCT）、C反应蛋白（CRP）、白介素-6（IL-6）的表达水平低于对照组（P<0.05）。治疗后，研究组CD8⁺低于对照组，CD3⁺、CD4⁺、CD4⁺/CD8⁺高于对照组（P<0.05）。研究组的咳嗽、呼吸困难、喘鸣音症状缓解时间短于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：RSV感染肺炎患儿采用热毒宁注射液联合更昔洛韦注射液治疗，疗效确切，能有效降低血清炎症因子水平，改善机体免疫功能，改善患儿临床症状，安全性较好。

Effect of Reduning Injection Combined with Ganciclovir Injection on Serum Inflammatory Factors and T cell Subsets in Children with Respiratory Syncytial Virus Infection Pneumonia

ABSTRACT Objective: To observe the effect of Reduning injection combined with ganciclovir injection on serum inflammatory factors and T cell subsets in children with respiratory syncytial virus (RSV) infection pneumonia. Methods: 60 children with RSV pneumonia were selected who were treated in our hospital from January 2017 to December 2020, and they were randomly divided into control group and study group, 30 cases in each group. The control group was treated with ganciclovir injection, and the study group was treated with Reduning injection combined with ganciclovir injection for 7 d. The curative effect, serum inflammatory factors, T cell subsets, symptom relief time and adverse reactions were compared between the two groups. Results: The total effective rate of the study group was 93.33%, which was higher than 66.67% of the control group (P<0.05). After treatment, the expression levels of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in the study group were lower than those in the control group (P<0.05). After treatment, the expression level of CD8⁺ in the study group was lower than that in the control group , CD3⁺, CD4⁺, CD4⁺/ CD8⁺ in the study group were higher than those in the control group(P<0.05). The remission time of cough, dyspnea and wheezing in the study group was shorter than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Reduning injection combined with ganciclovir injection is effective in the treatment of children with RSV infection pneumonia. It can effectively improve the clinical symptoms, reduce the level of serum inflammatory factors, improve the immune function of the body, and has good safety.