缺氧性肺动脉高压的治疗进展 |
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引用本文: | 钟士杰,邓 堂,林开文,廖 勇,魏胜超,李 奇,徐双琴,云宏芳,金桂云. 缺氧性肺动脉高压的治疗进展[J]. 现代生物医学进展, 2021, 0(18): 3596-3600 |
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作者姓名: | 钟士杰 邓 堂 林开文 廖 勇 魏胜超 李 奇 徐双琴 云宏芳 金桂云 |
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作者单位: | 海南医学院第一附属医院急危重症医学部 海南 海口570000;海南医学院急救与创伤研究教育部重点实验室 海南 海口570000 |
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基金项目: | 国家自然科学基金项目(31560267) |
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摘 要: | 摘要:缺氧性肺动脉高压(HPH)是指由于长期缺氧导致血管内皮细胞损伤,血管活性因子水平失调,以血管收缩及血管重塑为主要病理表现的一类肺动脉高压症(PAH),HPH发病率高,死亡率高,除了肺移植,目前尚无根治办法,对于HPH的治疗一直是研究热点,本文将结合近年国内外最新研究从基因靶向、离子通道、线粒体、NO相关药物、西药、中药领域对HPH的治疗做一概述。
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关 键 词: | 缺氧性肺动脉高压;HPH;治疗;机制 |
收稿时间: | 2021-01-03 |
修稿时间: | 2021-01-26 |
Progress in Treatment of Hypoxic Pulmonary Hypertension |
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Abstract: | ABSTRACT: Hypoxic pulmonary hypertension (HPH) refers to a type of pulmonary arterial hypertension (PAH) with vasoconstriction and vascular remodeling as the main pathological manifestations of vascular endothelial cell damage caused by long-term hypoxia, the incidence of HPH High mortality rate. Except for lung transplantation, there is currently no cure. The treatment of HPH has always been a research hotspot. This article will combine the latest research at home and abroad in recent years from gene targeting, ion channels, mitochondria, NO-related drugs, western medicine, and traditional Chinese medicine. The field gives an overview of the treatment of HPH. |
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Keywords: | Hypoxic pulmonary hypertension HPH Treatment Mechanism |
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