复明片联合曲伏前列素滴眼液对原发性开角型青光眼患者眼部血流动力学和房水EPO、sCD44的影响

摘要 目的：探讨复明片联合曲伏前列素滴眼液对原发性开角型青光眼（POAG）患者眼部血流动力学和房水促红细胞生成素（EPO）、可溶性CD44（sCD44）的影响。方法：选择2017年4月~2020年11月在本院接受治疗的112例193眼的POAG患者，根据随机数字表法分为对照组（n=56，96眼）和研究组（n=56，97眼），对照组患者接受曲伏前列素滴眼液治疗，研究组接受复明片联合曲伏前列素滴眼液治疗，对比两组疗效、眼部血流动力学和房水EPO、sCD44，视力、视野、眼压，观察治疗期间不良反应发生状况。结果：研究组的临床总有效率高于对照组（P<0.05）。治疗12周后，研究组平均光敏感度（MS）、视力高于对照组，24 h眼压平均值小于对照组（P<0.05）。治疗12周后，研究组舒张末期流速（EDV）、收缩期峰值流速（PSV）高于对照组，血流阻力系数（RI）小于对照组（P<0.05）。治疗12周后，研究组房水EPO、sCD44水平低于对照组（P<0.05）。两组不良反应发生率组间对比无统计学差异（P>0.05）。结论：复明片联合曲伏前列素滴眼液治疗POAG患者，可促进患者视力、视野、眼压改善，可能与调节眼部血流动力学和房水EPO、sCD44水平有关。

Effects of Fuming Tablets Combined with Travoprost Eye Drops on Ocular Hemodynamics, Aqueous EPO and sCD44 in Patients with Primary Open-Angle Glaucoma

ABSTRACT Objective: To investigate the effects of Fuming tablets combined with travoprost eye drops on ocular hemodynamics, aqueous erythropoietin (EPO) and soluble CD44 (sCD44) in patients with primary open-angle glaucoma (POAG). Methods: 112 cases (193 eyes) of POAG who were treated in our hospital from April 2017 to November 2020 were selected, according to the random number table method, they were divided into control group (n=56, 96 eyes) and study group (n=56, 97 eyes). Patients in the control group were treated with travoprost eye drops, and patients in the study group were treated with Fuming tablets combined with travoprost eye drops. The efficacy, ocular hemodynamics, aqueous EPO, sCD44, visual acuity, visual field and intraocular pressure of the two groups were compared, and the occurrence of adverse reactions during the treatment period were observed. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). 12 weeks after treatment, mean light sensitivity (MS) and visual acuity of the study group were higher than those of the control group, and the 24h mean intraocular pressure was lower than that of the control group (P<0.05). 12 weeks after treatment, the end diastolic velocity (EDV) and peak systolic velocity (PSV) of the study group were higher than those of the control group, and the blood flow resistance coefficient (RI) was lower than that of the control group (P<0.05). 12 weeks after treatment, EPO and sCD44 of the study group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Fuming tablets combined with travoprost eye drops can improve the visual acuity, visual field and intraocular pressure of patients with POAG, which may be related to the regulation of ocular hemodynamics and the levels of EPO and sCD44 in aqueous humor.