银杏叶提取物注射液联合地塞米松对突发性耳聋患者血液流变学、内皮功能及外周血T淋巴细胞亚群的影响

摘要 目的：探讨银杏叶提取物注射液联合地塞米松对突发性耳聋患者内皮功能、血液流变学及外周血T淋巴细胞亚群的影响。方法：选取2018年1月到2019年12月我院收治的100例突发性耳聋患者，将纳入病例依照随机数字表法分为对照组（n=50，给予鼓室注射地塞米松治疗）和观察组（n=50，对照组基础上静脉滴注银杏叶提取物注射液），两组疗程均为10 d。对比两组疗效、血液流变学、内皮功能、外周血T淋巴细胞亚群、纯音听阈值及不良反应。结果：观察组治疗10 d后的临床总有效率为96.00%，高于对照组的82.00%（P<0.05）。观察组治疗10 d后纯音听阈值明显较对照组小（P<0.05）。观察组治疗10 d后纤维蛋白原、全血高切黏度、全血低切黏度低于对照组（P<0.05）。观察组治疗10 d后可溶性血管细胞间黏附分子-1 (sVCAM-1)、内皮素-1（ET-1）低于对照组（P<0.05）。观察组10 d后CD8⁺较对照组低，CD3⁺、CD4⁺/CD8⁺、CD4⁺较对照组高（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：采用银杏叶提取物注射液联合地塞米松治疗突发性耳聋患者，可有效改善内皮功能和血液流变学，提高机体免疫功能，效果确切，安全性佳。

Effects of Ginkgo Biloba Extract Injection Combined with Dexamethasone on Hemorheology, Endothelial Function and Peripheral Blood T Lymphocyte Subsets in Patients with Sudden Deafness

ABSTRACT Objective: To investigate the effects of Ginkgo biloba extract injection combined with dexamethasone on hemorheology, endothelial function and peripheral blood T lymphocyte subsets in patients with sudden deafness. Methods: 100 patients with sudden deafness were selected from January 2018 to December 2019 in our hospital. The patients were randomly divided into control group (n=50, tympanum injection of dexamethasone treatment)and observation group (n=50, Ginkgo biloba extract injection on the basis of the control group) by random number table method, the course of treatment was 10 d in both groups. The curative effect, hemorheology, endothelial function, peripheral blood T lymphocyte subsets, pure tone hearing threshold and adverse reactions were compared between the two groups. Results: 10 days after treatment, clinical total effective rate of observation group was 96.00%, which was higher than that of control group (82.00%)(P<0.05). 10 days after treatment, the pure tone hearing threshold of observation group was significantly lower than control group(P<0.05). 10 days after treatment, fibrinogen, whole blood high shear viscosity and whole blood low shear viscosity in observation group were lower than control group(P<0.05). 10 days after treatment, the levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and endothelin-1(ET-1) in observation group were lower than the control group (P<0.05). After 10 days, CD8⁺ in observation group was lower than the control group, and CD3⁺, CD4⁺/CD8⁺, CD4⁺ were higher than those in the control group (P<0.05). There was no difference in incidence of adverse reactions between two groups(P>0.05). Conclusion: Patients with sudden deafness are treated with Ginkgo biloba extract injection combined with tympanum injection of dexamethasone, which can effectively improve endothelial function and hemorheology, improve the immune function of the body, with accurate effect and has a good safety.