口腔扁平苔藓患者血清白介素-17、P物质、趋化素水平与疾病活动和免疫功能的关系研究

摘要 目的：研究口腔扁平苔藓（OLP）患者血清白介素-17（IL-17）、P物质（SP）、趋化素（Chemerin）水平与疾病活动和免疫功能的关系。方法：选取我院2019年3月~2021年5月期间收治的117例OLP患者作为观察组，其中非糜烂型69例，糜烂型48例。另选取同期来我院体检的健康志愿者60例为对照组。对比对照组及不同分型患者血清SP、IL-17、Chemerin水平，对比不同分型患者的疾病活动相关评分和免疫功能指标，应用Pearson相关分析血清SP、IL-17、Chemerin水平与疾病活动相关评分和免疫功能指标的相关性。结果：不同分型OLP患者血清SP、IL-17、Chemerin水平均高于对照组（P<0.05），且糜烂型OLP患者的血清SP、IL-17、Chemerin水平高于非糜烂型OLP患者（P<0.05）。糜烂型OLP患者的CD3⁺、CD4⁺低于非糜烂型OLP患者（P<0.05），糜烂型OLP患者的CD8⁺、免疫球蛋白M（IgM）水平、OLP网纹-糜烂-溃疡疾病活动积分（REU）总分高于非糜烂型OLP患者（P<0.05）。糜烂型与非糜烂型OLP患者间免疫球蛋白A（IgA）、免疫球蛋白G（IgG）水平对比差异无统计学意义（P>0.05）。Pearson相关性分析结果显示，血清SP、IL-17、Chemerin水平与IgM水平、REU总分均呈正相关（P<0.05）。结论：OLP患者血清IL-17、SP、Chemerin水平异常升高，三者共同参与了OLP患者的病情进展及免疫功能调节。

Relationship Study between Serum Interleukin-17, Substance P, Chemokine Levels and Disease Activity and Immune Function in Patients with Oral Lichen Planus

ABSTRACT Objective: To study the relationship between serum interleukin-17 (IL-17), substance P (SP), chemokine (Chemerin) levels and disease activity and immune function in patients with oral lichen planus (OLP). Methods: 117 patients with OLP who were treated in our hospital from March 2019 to May 2021 were selected as the observation group, including 69 cases of non erosive type, and 48 cases of erosive type. Another 60 volunteers who came to our hospital for physical examination in the same period were selected as the control group. The serum SP, IL-17 and Chemerin levels in the control group and patients with different types were compared, and the disease activity related scores and immune function indexes of patients with different types were compared. Pearson correlation analysis was used to analyze the relationship between serum SP, IL-17, Chemerin levels and disease activity related scores and immune function indexes. Results: The serum SP, IL-17 and Chemerin levels of the OLP patients with different types were higher than those of the control group (P<0.05). The serum SP, IL-17 and Chemerin levels of erosive type OLP patients were higher than those of non erosive type OLP patients (P<0.05). The CD3⁺ and CD4⁺ of erosive type OLP patients were lower than those iof non erosive type OLP patients (P<0.05). The CD8⁺, immunoglobulin M (IgM) level and the total scores of reticulo erosive ulcer disease activity score (REU) of erosive type OLP patients were higher than those of non type erosive OLP patients (P<0.05). There was no significant difference in immunoglobulin A (IGA) and immunoglobulin G (IgG) levels between erosive and non erosive OLP patients (P>0.05). Pearson correlation analysis showed that serum SP, IL-17 and Chemerin levels were positively correlated with the total scores of IgM level and REU total score (P<0.05). Conclusion: The serum IL-17, SP and Chemerin levels in patients with OLP are abnormally increased. They are involved in the disease progression and immune function regulation of patients with OLP.