IgA肾病合并高尿酸血症患者的危险因素分析

摘要 目的：探讨IgA肾病合并高尿酸血症患者的危险因素。方法：回顾性分析2018年1月至2021年1月于我院进行治疗的IgA肾病患者149例的病理资料，根据高尿酸血症发生情况分为高尿酸血症组（n=65），正常尿酸组（n=84）。比较两组病理特征，收集患者年龄、性别、BMI、性别、高血压、血肌酐、尿素氮、血白蛋白、血胆固醇、甘油三酯、24 h尿蛋白定量、IL-6、IL-1及胱抑素C及CRP等资料，分析高尿酸血症发生的危险因素。结果：两组患者年龄、BMI、CRP差异无统计学意义（P>0.05）；性别、高血压、血肌酐、尿素氮、血白蛋白、血胆固醇、甘油三酯、24 h尿蛋白定量、IL-6、IL-1及胱抑素C与IgA肾病患者发生高尿酸血症相关（P<0.05）；高尿酸组患者球性硬化、节段硬化、新月体形成、小管萎缩、间质炎性浸润及间质纤维化发生率均显著高于正常尿酸组，差异显著（P<0.05）；多因素非条件Logistic分析显示，性别、高血压、血肌酐、尿素氮、血白蛋白、血胆固醇、甘油三酯、24 h尿蛋白定量、IL-6、IL-1及胱抑素C均是IgA肾病患者发生高尿酸血症的独立危险因素（P<0.05）。结论：患者性别、高血压、血肌酐、尿素氮、血白蛋白、血胆固醇、甘油三酯、24 h尿蛋白定量、IL-6、IL-1及胱抑素C均是IgA肾病患者发生高尿酸血症的危险因素，临床上对于具有危险因素的患者引起重视，提高治疗效果。

Analysis of the Risk Factors in IgA Nephropathy with Hyperuricemia

ABSTRACT Objective: To study Analysis of theRisk factors in IgA nephropathy with hyperuricemia. Methods: The pathological data of 149 patients with IgA nephropathy treated in our hospital from January 2018 to January 2021 were retrospectively analyzed. According to the occurrence of hyperuricemia, they were divided into hyperuricemia group (n=65) and normal uric acid group (n=84). The pathological characteristics of the two groups were compared. The data of patients'' age, gender, BMI, gender, hypertension, serum creatinine, urea nitrogen, serum albumin, blood cholesterol, triglyceride, 24 h urine protein, IL-6, IL-1, cystatin C and CRP were collected to analyze the risk factors of hyperuricemia. Results: There were no significant differences in age, BMI and CRP between 2 groups (P>0.05). Gender, hypertension, serum creatinine, urea nitrogen, serum albumin, serum cholesterol, triglyceride, 24 h urinary protein, IL-6, IL-1 and cystatin C were correlated with hyperuricemia in patients with IgA nephropathy (P<0.05). The incidence of bulbar sclerosis, segmental sclerosis, crescent formation, tubule atrophy, interstitial inflammatory infiltration and interstitial fibrosis in high uric acid group was significantly higher than that in normal uric acid group, the difference was significant(P<0.05); Multivariate Logistic analysis showed that gender, hypertension, serum creatinine, urea nitrogen, serum albumin, blood cholesterol, triglyceride, 24 h urinary protein level, IL-6, IL-1 and cystatin C were all independent risk factors for hyperuricemia in patients with IgA nephropathy(P<0.05). Conclusion: Patients'' gender, hypertension, serum creatinine, urea nitrogen, serum albumin, blood cholesterol, triglyceride, 24h urine protein, IL-6, IL-1 and cystatin C are all risk factors for hyperuricemia in patients with IgA nephropathy. Clinical attention should be paid to patients with risk factors to improve the treatment effect.