麒麟丸联合炔雌醇环丙孕酮对多囊卵巢综合征致不孕症患者子宫内膜容受性、血清性激素和氧化应激水平的影响

摘要 目的：探讨麒麟丸联合炔雌醇环丙孕酮对多囊卵巢综合征（PCOS）致不孕症患者子宫内膜容受性、血清性激素和氧化应激水平的影响。方法：选取我院于2018年1月~2020年1月期间收治的PCOS致不孕症患者460例，符合要求的患者按照随机数字表法分为对照组和研究组，各为230例。对照组患者予以炔雌醇环丙孕酮治疗，研究组予以麒麟丸联合炔雌醇环丙孕酮治疗，对比两组疗效、子宫内膜容受性、性激素、氧化应激、排卵率、妊娠率和不良反应。结果：研究组的临床总有效率较对照组更高（P<0.05）。研究组治疗后子宫动脉搏动指数（PI）、子宫动脉血流阻力指数（RI）低于对照组，子宫内膜厚度大于对照组（P<0.05）。研究组治疗后促卵泡激素（FSH）和黄体生成素（LH）低于对照组，雌二醇（E2）高于对照组（P<0.05）。研究组治疗后丙二醛（MDA）、活性氧物质（ROS）低于对照组，过氧化物歧化酶（SOD）高于对照组（P<0.05）。随访6个月后，研究组的妊娠率、排卵率明显高于对照组（P<0.05）。两组不良反应发生率组间对比无差异（P>0.05）。结论：麒麟丸联合炔雌醇环丙孕酮治疗PCOS致不孕症患者，可以有效改善患者子宫内膜容受性、血清性激素和氧化应激状态，提高妊娠率、排卵率，安全有效。

Effects of Qilin Pill Combined with Ethinylestradiol and Cyproterone on Endometrial Receptivity, Serum Sex Hormones and Oxidative Stress Levels in Infertile Patients with Polycystic Ovary Syndrome

ABSTRACT Objective: To investigate the effects of Qilin pill combined with ethinylestradiol and cyproterone on endometrial receptivity, serum sex hormones and oxidative stress levels in infertile patients with polycystic ovary syndrome (PCOS). Methods: A total of 460 infertility patients with PCOS in our hospital from January 2018 to January 2020 were selected. The patients who met the requirements were randomly divided into control group and study group, 230 cases in each group. The control group was treated with ethinylestradiol and cyproterone, while the study group was treated with Qilin pill combined with ethinylestradiol and cyproterone. The efficacy, endometrial receptivity, sex hormone, oxidative stress, ovulation rate, pregnancy rate and adverse reactions of the two groups were compared. Results: The total effective rate of the study group was higher than that of the control group(P<0.05). After treatment, the uterine artery pulsatility index(PI) and uterine artery resistance index (RI) of the study group were lower than those of the control group, and the endometrial thickness was greater than that of the control group (P<0.05). After treatment, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) of the study group were lower than those of the control group, and the estradiol (E₂) of the study group was higher than that of the control group (P<0.05). After treatment, malondialdehyde (MDA) and reactive oxygen species (ROS) of the study group were lower than those of the control group, while superoxide dismutase (SOD) was higher than that of the control group (P<0.05). After 6 months of follow-up, the pregnancy rate and ovulation rate of the study group were significantly higher than those of the control group(P<0.05). There was no difference in the incidence rate of adverse reactions between the two groups(P>0.05). Conclusion: Qilin pill combined with ethinylestradiol and cyproterone in the treatment of infertility patients with PCOS, can effectively improve the endometrial receptivity, serum sex hormone and oxidative stress state of patients, improve pregnancy rate, ovulation rate, safe and effective.