超声心动图检查指标与胎儿染色体异常的相关性

摘要 目的：探究超声心动图检查指标与胎儿染色体异常之间的相关性。方法：选择2017年1月至2020年1月于我院接受产前超声心动图检查的980例高危产妇为研究对象，均对其开展超声心动图以及染色体核型检测，记录受检者染色体核型异常具体情况，筛选出染色体核型异常产妇（80例）作为研究组，设另900例染色体正常产妇为对照组，就两组产妇的超声心动图检查指标左心室Tei指数、右心室Tei指数以及颈项透明层厚度（NT）值差异进行比较，Spearman相关性分析探究上述超声心动图指标的相关性，最后绘制心动图指标对染色体异常的诊断ROC曲线图并计算AUC值。结果：（1）比较显示研究组胎儿的左心室Tei指数、右心室Tei指数和NT值均明显的高于对照组胎儿，组间差异具有统计学意义（P<0.05）；（2）相关性分析显示NT值同染色体异常胎儿的左心室Tei值、右心室Tei值均呈现明显的正相关联系（r=0.8927，r=0.9315，P<0.0001）；（3）ROC曲线绘制显示左心室Tei值、右心室Tei值和NT值对胎儿染色体异常的诊断AUC分别为0.9889、0.7574、0.7959（P<0.05）。结论：超声心动图检查指标同胎儿的染色体异常之间存在明显的关联性，可以考虑将超声心动图作为胎儿染色体异常的初筛手段，推广于临床应用。

Correlation between Echocardiographic Indexes and Fetal Chromosomal Abnormalities

ABSTRACT Objective: To explore the correlation between the indexes of echocardiography and fetal chromosomal abnormalities. Methods: A total of 980 high-risk pregnant women, who received prenatal echocardiography in Northwest Women and Children''s Hospital from January 2017 to January 2020, were chosen as research subjects, and their echocardiography and chromosomal karyotype detection were carried out, and the specific situation of chromosomal karyotype abnormality was recorded to screen out chromosomal karyotype abnormality Maternal (80 cases) as study group, another 900 cases of normal maternal chromosome as control group. The maternal echocardiography indicators left ventricular Tei index, right ventricular Tei index and neck translucent layer thickness (NT) value differences were compared between the two groups. The correlation of the above echocardiographic indicators were explored by Spearman correlation analysis, and a graph of the diagnostic value of echocardiographic indicators for fetal chromosomal abnormalities was finally drawn. Results: (1) The Tei index of left ventricle, Tei index of right ventricle and NT value of the study group were significantly higher than those of the control group, and the difference between the two groups was statistically significant (P<0.05). (2) Correlation analysis showed that NT value was positively correlated with Tei value of left ventricle and TEI value of right ventricle (r=0.8927). (3) ROC curve showed that the AUC of TEI value in left ventricle, TEI value in right ventricle and NT value in the diagnosis of fetal chromosomal abnormalities were 0.9889, 0.7574 and 0.7959 respectively(P<0.05). Conclusion: There is a significant correlation between echocardiographic indexes and fetal chromosomal abnormalities. Echocardiography can be considered as a screening method for fetal chromosomal abnormalities in the clinical application.