血清血管内皮细胞生长因子和碱性成纤维细胞生长因子水平变化对服药自杀青少年心理状况的影响

摘要 目的：研究服药自杀青少年血清血管内皮细胞生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）变化，及其与患者心理状况的相关性。方法：纳入2018年1月到2020年12月四川大学华西医院收治的服药自杀青少年81例（研究组），同时纳入81例健康志愿者作为对照（对照组）。检测两组研究对象血清VEGF和bFGF水平，并使用汉密顿抑郁量表（HAMD）、抑郁自评量表（SDS）和自杀意念自评量表（SlOSS）评估两组患者心理状态。结果：两组研究对象性别、年龄、身高以及体质指数（BMI）具有可比性（P>0.05）；研究组吸烟者比例（16/81）和有家族精神病史比例（13/81）均显著高于对照组（6/81和3/81）（P<0.05）。研究组服药自杀青少年血清VEGF（699.72±103.42）ng/mL和bFGF（348.31±65.13）ng/mL水平均高于与对照组健康志愿者（620.31±85.32）ng/mL和（265.37±35.23）ng/mL]（P<0.05），并且与是否吸烟或有无家族精神疾病史无关（P<0.05）。Pearson相关性分析结果显示：服药自杀青少年血清VEGF和BFGF均与HAMD和SDS评分无相关，与SIOSS评分均呈正相关（r=0.278和r=0.302，均P<0.05）。结论：服药自杀青少年血清VEGF和bFGF水平升高，与自杀意念自评量表得分有正相关。

Changes in Serum Vascular Endothelial Cell Growth Factor and Basic Fibroblast Growth Factor Levels in Adolescents who Committed Suicide by Taking Drugs and Their Correlation with Psychological Status

ABSTRACT Objective: To study the changes of serum vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF) in adolescents who committed suicide by taking drugs, and their correlation with the psychological status of patients. Methods: From January 2018 to December 2020, 81 adolescents (research group) who attempted suicide by taking drugs admitted to West China Hospital of Sichuan University were included, and 81 healthy volunteers were included as controls(control group). Detect the serum VEGF and bFGF levels of the two groups of subjects, and use the Hamilton Depression Scale (HAMD), Self-Rating Depression Scale (SDS) and Self-Rating Suicide Ideation Scale (SlOSS) to assess the mental status of the two groups of patients. Results: The gender, age, height and body mass index(BMI) of the two groups of study subjects are comparable(P>0.05). The proportion of smokers in the study group(16/81) and the proportion of family psychiatric history(13/81) were significantly higher than those of the control Group (6/81 and 3/81)(P<0.05). The serum VEGF(699.72±103.42) ng/mL and bFGF(348.31±65.13) ng/mL levels of the study group suicide teenagers were higher than those of the control group healthy volunteers (620.31±85.32) ng/mL and (265.37±35.23) ng/mL](P<0.05), and has nothing to do with smoking or family history of mental illness(P<0.05). The results of Pearson correlation analysis showed that serum VEGF and bFGF of adolescents who committed suicide had no correlation with HAMD and SDS scores, but were positively correlated with SIOSS scores(r=0.278 and r=0.302, both P<0.05). Conclusion: The levels of serum VEGF and bFGF in suicide adolescents who took medicine were elevated, which was positively correlated with the scores of the self-rating suicide ideation scale.