不同放射剂量CT在早期非小细胞肺癌中筛检价值对比

摘要 目的：探讨与对比不同放射剂量计算机断层扫描(Computed Tomography，CT)在早期非小细胞肺癌中筛检价值。方法：2020年1月到2020年12月选择在本院经病理确诊为肺内磨玻璃样结节患者98例作为研究对象，所有患者都给予常规剂量正电子发射计算机断层扫描(Positron emission tomography，PET)/CT检查与低剂量PET/CT检查，记录成像特征、辐射剂量并判定筛检价值。结果：低剂量PET/CT对肺部增厚、边界不规则、钙化、囊变的检出率高于常规剂量PET/CT(P<0.05)。低剂量PET/CT与常规剂量PET/CT的图像质量优良率为98.0 %和96.9 %，对比差异无统计学意义(P>0.05)。低剂量PET/CT的有效放射剂量、剂量长度乘积低于常规剂量PET/CT(P<0.05)。低剂量PET/CT的最大标准摄取值(maximum standardized uptake value，SUVmax)值低于常规剂量PET/CT(P<0.05)。低剂量PET/CT与常规剂量PET/CT分别筛检非小细胞肺癌51例与37例，筛检敏感性分别为98.1 %和69.2 %，特异性分别为100.0 %和97.8 %。结论：低放射剂量PET/CT在肺结节中的应用不会影响图像质量，且能降低辐射剂量，提高对早期非小细胞肺癌患者的筛检效果。

Comparison of the Value of CT with Different Radiation Doses in Screening Early Non-small Cell Lung Cancer

ABSTRACT Objective: To explore and compare the value of computer tomography(CT) with different radiation doses in the screening of early non-small cell lung cancer. Methods: From January 2020 to December 2020, 98 cases of patients with ground glass nodules in the lungs diagnosed pathologically in our hospital were selected as the research subjects. All cases were given conventional-dose positron emission tomography(PET)/CT examination and low-dose PET/CT examination, recorded the imaging characteristics, radiation dose and determined the value of screening. Results: The detection rates of low-dose PET/CT for lung thickening, irregular borders, calcification, and cystic degeneration were higher than that of conventional-dose PET/CT(P<0.05). The excellent and good image quality rates of low-dose PET/CT and conventional-dose PET/CT were 98.0 % and 96.9 %, and the difference were not statistically significant(P>0.05). The effective radiation dose and dose length product of low-dose PET/CT were lower than conventional-dose PET/CT(P<0.05). The maximum standardized uptake value(SUVmax) of low-dose PET/CT were lower than that of regular-dose PET/CT(P<0.05). Low-dose PET/CT and conventional-dose PET/CT were used to screen 51 and 37 cases of non-small cell lung cancer, respectively, so that the screening sensitivity were 98.1% and 69.2%, and the specificity were 100.0 % and 97.8 %, respectively. Conclusion: The application of low-dose PET/CT in pulmonary nodules will not affect the image quality, and can reduce the radiation dose and improve the screening effect for patients with early non-small cell lung cancer.