Increased micronucleus frequency after oral administration of cadmium in dogs |
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Authors: | Hamiyet Dönmez-Altuntas Zuhal Hamurcu Narin Liman Halil Demirtas Nalan Imamoglu |
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Institution: | (1) Department of Medical Biology, Medical Faculty, Erciyes University Kayseri, Turkey;(2) Department of Histology and Embryology, Veterinary Faculty, Erciyes University Kayseri, Turkey |
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Abstract: | Cadmium (Cd) is a toxic heavy metal that has been classified as a human carcinogen by the International Agency for Research
on Cancer. The genotoxic effects of cadmium oxide (CdO) were investigated in cultured dog lymphocytes after a short-term oral
CdO administration by the micronucleus (MN) test. The dogs were given 10 mg CdO/kg body weight per day for 3 and 28 d, respectively
group I (n=7) and group II (n=6). Blood samples were collected at the beginning of feeding and at 4 and 29 d after Cd administration and cultured for 72
h. Whereas no significant increase in the MN frequency in group I was observed (p=0.398), a significant MN induction with CdO was found in group II (p=0.028) when compared with initial MN frequencies of dogs in both groups. Our results suggest that CdO might be directly and/or
indirectly genotoxic after a monthly oral administration of CdO in dogs. |
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Keywords: | Cadmium cadmium oxide dogs feed micronucleus |
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