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Molecular complexes of ivy and licorice saponins with sildenafil citrate (Viagra) and their biological activity |
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| Authors: | L A Yakovishin A V Lekar E V Vetrova N I Borisenko S N Borisenko V I Grishkovets |
| Institution: | 1. Sevastopol National Technical University, ul. Universitetskaya 33, Sevastopol, 99053, Ukraine 2. Institute of Physical and Organic Chemistry, Southern Federal University, pr. Stachki 194/2, Rostov-on-Don, 344090, Russia 3. Ecological and Analytical Center, Southern Federal University, ul. Zorge 7, Rostov-on-Don, 344090, Russia 4. Vernadsky Taurida National University, pr. Vernadsky 4, Simferopol, 95007, Ukraine |
| Abstract: | The molecular complexation of triterpene glycosides α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranoside), hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(l → 4)-O-β-D-glucopyranosyl-(l → 6)-O-β-D-glucopyranoside), and glycyram (monoammonium glycyrrhizinate) with sildenafil citrate was investigated for the first time using electrospray ionization mass spectroscopy. The glycosides form a complex in a 1: 1 molar ratio. The influence of the complex on Avena sativa seeds germination and its ichthyotoxicity against Poecilia reticulata were studied. |
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