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New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy |
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| Authors: | Isabelle Meunier Ravindra K. Pandey Michelle M. Walker Mathias O. Senge Thomas J. Dougherty Kevin M. Smith |
| Affiliation: | a Department of Chemistry, University of California, Davis, CA 95616, U.S.A. b Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, U.S.A. |
| Abstract: | An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study. |
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