放疗联合热疗治疗68例晚期卵巢癌术后复发的放疗联合热疗临床观察

目的:探讨放疗联合热疗治疗晚期卵巢癌术后复发的临床疗效。方法:选择哈医科大学第四临床医院及黑龙江省第二肿瘤医院2010年3月~2013年3月收治的68例卵巢癌术后复发患者(均为术后化疗6-8个疗程盆腔复发),将其随机分为热疗联合放疗组(实验组)和单纯化疗组(对照组)。所有患者均给予化疗6-8个周期以上,实验组在放疗结束后2小时内进行热疗,2次/周,共6-8周。通过影像学检查治疗前后肿瘤体积的变化进行疗效评估,观察两组治疗期间各种不良反应的发生情况及术后3年的生存情况。结果:观察组肿瘤完全缓解率(CR)实验组明显高于对照组(P0.05)。皮肤损伤的发生率显著高于对照组,而白细胞计数下降的发生率明显低于对照组(P0.05)。两组随访1、2年的生存率无明显差异(P0.05),实验组第3年的生存率明显高于对照组(P0.05)。结论:热疗联合放疗可提高晚期卵巢癌术后复发的临床疗效。

Clinical Observation on Radiotherapy Combined with High Frequency Thermotherapy in the Treatment of 68 Advanced Ovarian Cancer Patients of Recurrence after Surgery

Objective:To observe the clinical efficacy of radiotherapy combined with high frequency thermotherapy for the treatment of advanced ovarian cancer recurrence after surgery.Methods:68 cases of advanced ovarian cancer admitted in the Fourth Affiliated Hospital of Haerbin Medical University and Heilongjiang Land Reclamation General Hospital from March 2010 to March 2013 who were recurrent 6-8 treatment cycles after surgery were selected and randomly divided into the experiment group (radiotherapy combined with high frequency thermotherapy) and control group(chemotherapy). All the patients were treated for at least 4 treatment cycles, the experiment group was given high frequency thermotherapy in 2 hours after radiotherapy, twice a week, in total 6-8 weeks. The clinical efficacy was evaluated by the changes of tumor volume using imageological examination. The incidence of adverse reactions during treatment and survival condition 3 years after surgery were observed and compared.Results:After four cycles of treatment, the complete remission( CR) rate of experiment group was significantly higher than that of the control group(P<0.05); The incidence rate of skin injury of experiment group was significantly higher than that of the control group, but the incidence rate of leukopenia was significantly lower than that of the control group (P<0.05). No significant difference was found in the 1-year and 2-year survival rate between two groups, but the 3-year survival rate was significantly higher in the experiment group than the control group(P<0.05).Conclusion:Radiotherapy combined with high frequency thermotherapy could effectively enhanced the clinical efficacy of .advanced ovarian cancer recurrence after surgery.