| 水通道蛋白4与脑水肿研究进展 |
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| 引用本文： | 夏文政 胡韶山. 水通道蛋白4与脑水肿研究进展[J]. 现代生物医学进展, 2015, 15(4): 768-770 |
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| 作者姓名： | 夏文政 胡韶山 |
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| 作者单位： | 哈尔滨医科大学附属第二医院 |
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| 基金项目： | 黑龙江省新世纪优秀人才支持计划(1153-NECT-012);教育部新世纪优秀人才支持计划(NECT-09-0131) |
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| 摘 要： | 水通道蛋白4(AQP4)是膜水通道蛋白家族的一员,在脑组织中高表达,是控制水进出脑组织的通道。近年来发现,AQP4的功能和表达与脑水肿密切相关。同时脑水肿又是和脑疾病治疗密切相关的病理过程,对两者的研究或许可以为我们带来更多的临床治疗新思路。本文综述了AQP4的结构、表达、调控与功能以及AQP4与脑水肿关系的研究进展。
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| 关 键 词： | 水通道蛋白4 脑水肿 调节作用 |
Research Progress of AQP4 and Brain Edema |
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| XIA Wen-zheng;HU Shao-shan. Research Progress of AQP4 and Brain Edema[J]. Progress in Modern Biomedicine, 2015, 15(4): 768-770 |
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| Authors: | XIA Wen-zheng HU Shao-shan |
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| Affiliation: | XIA Wen-zheng;HU Shao-shan;The Second Affiliated Hospital of Harbin Medical University; |
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| Abstract: | AQP4 is one of the aquaporins, which is widely expressed in the brain tissue, and is the channel in the brain tissuecontrolling water pass in and out. In recent years, the function and expression of AQP4 was found to be closely related to brain edema. Inthe same time, brain edema is the pathological progress which is closely related to brain diseases. The research of the two may bring usmore new ideas of clinical treatment. This paper reviewed the structure, expression, regulation, function of AQP4 and the advances inAQP4 and brain edema research. |
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| Keywords: | AQP4 Brain edema Regulation function |
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