阿司匹林引发上消化道出血的相关危险因素研究

目的:比较由阿司匹林引发上消化道出血的相关危险因素OR值,探讨其引起消化道大出血的相关机制。方法:收集哈医大四院消化内科及心内科2009年5月份至2013年6月份仅口服阿司匹林一种非甾体抗炎药的100例患者,用药过程中引发上消化道出血的49例患者作为研究组,其余未发生消化道出血的51例患者作为对照组,采集现病史、既往史、吸烟史、行凝血常规、Hp检测及胃镜检查,经单因素统计分析筛选出阿司匹林引发上消化道出血的危险因素;通过多元Logistic回归分析得出阿司匹林引发上消化道出血的独立危险因素。结果:年龄60岁、Hp感染、既往溃疡病史、糖尿病、吸烟的患者在研究组所占比例明显高于对照组,差异具有统计学意义;经多元Logistic回归后表明年龄60岁、Hp感染、既往溃疡病史、糖尿病患者和阿司匹林引发上消化道出血的OR值具有统计学差异。结论:年龄60岁、Hp感染、溃疡病史、糖尿病患者是阿司匹林引发上消化道出血的4个独立危险因素。

Aspirin Causes of Upper Gastrointestinal Bleeding Risk Factor Analysis

Objective:To compare the OR values of the risk factors that are associated with upper gastrointestinal hemorrhagecaused by aspirin.Methods:100 cases of patients who had taken aspirin orally as the only NSAID (non-steroidal anti-inflammatory drug)and hospitalized at Digestive System Department and Cardiology Department of the Fourth Affiliated Hospital of Harbin MedicalUniversity were selected, 49 cases of whomhad upper gastrointestinal bleeding caused by medicine were selected as research group, andthe other 51 cases were used as control group. History of present illness, past medical illness, smoking history, coagulation routine, HPtesting and gastroscopy were collected to screen out risk factors that led to upper gastrointestinal hermorrhage caused by aspirin throughsingle factor statistical analysis, and to work out the independent risk factors through multiple Logistic regression analysis.Results:Patients at age over 60 or with history of Hp infection, ulceration, diabetes, and smoking took an apparently higher rate in the researchgroup that in the control group, with statistical significance. Through multiple Logistic regression, it was indicated that there wasstatistical difference among age over 60 or with history of Hp infection, ulceration, diabetes, and the OR value of upper gastrointestinalhermorrhage caused by aspirin.Conclusion:Age over 60, history of Hp infection, ulceration, diabetes are risk factors which lead toupper gastrointestinal hermorrhage caused by aspirin.