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Aminotriazine 5-HT7 antagonists |
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| Authors: | Mattson Ronald J Denhart Derek J Catt John D Dee Michael F Deskus Jeffrey A Ditta Jonathan L Epperson James Dalton King H Gao Aiming Poss Michael A Purandare Ashok Tortolani David Zhao Yufen Yang Hua Yeola Suresh Palmer Jane Torrente John Stark Arlene Johnson Graham |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. mattsonr@bms.com |
| Abstract: | The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce no agonist effects by themselves, and shift the dose-response curve of 5-CT to the right in the manner of an antagonist. |
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