| 链激酶研究概况及其进展 |
| |
| 引用本文： | 张华山,闫俊鹏,齐义鹏,李亚芳,余响华. 链激酶研究概况及其进展[J]. 氨基酸和生物资源, 2006, 28(4): 71-73. DOI: 10.3969/j.issn.1006-8376.2006.04.020 |
| |
| 作者姓名： | 张华山 闫俊鹏 齐义鹏 李亚芳 余响华 |
| |
| 作者单位： | 湖北工业大学生物工程学院,武汉,430068;武汉大学生命科学学院,武汉,430072 |
| |
| 摘 要： | 链激酶(Streptok inase,SK)是世界上最早发现的纤维蛋白酶原激活剂,也是最早作为临床药品治疗血栓性疾病的溶栓酶。它是由A,C,G群链球菌中β-溶血性链球菌分泌的胞外非酶蛋白质,能和纤溶酶原结合,将纤溶酶原激活为纤溶酶,具有溶解血栓的作用。本文详细综述了该酶的性质、在溶栓酶中的地位、研究历史、作用机理等。此外,由于它有半衰期短、不具有纤维蛋白特异性、治疗后出血和血栓易复发的缺点,所以有必要用基因工程的手段进行改造,以达到更好的治疗效果。
|
| 关 键 词： | 链激酶 重组链激酶 纤溶酶原 |
| 文章编号： | 1006-8376(2006)04-0071-03 |
| 收稿时间： | 2006-06-27 |
| 修稿时间： | 2006-06-27 |
General Situation and Latest Progress on Streptokinase |
| |
| ZHANG Hua-Shan,YAN Jun-Peng,QI Yi-peng,LI Ya-fang,YU Xiang-hua. General Situation and Latest Progress on Streptokinase[J]. Amino Acids & Biotic Resources, 2006, 28(4): 71-73. DOI: 10.3969/j.issn.1006-8376.2006.04.020 |
| |
| Authors: | ZHANG Hua-Shan YAN Jun-Peng QI Yi-peng LI Ya-fang YU Xiang-hua |
| |
| Affiliation: | 1. College of Bioengineering of Hubei University of Technology, Wuhan 430068 ; 2. College of Life Science, WuHan University, Wuhan 430072, China |
| |
| Abstract: | Streptokinase(SK) was discovered as the first plasminogen activator in the world,and it was the earliest clinical agent to cure thrombus.Streptokinase is an extracellular protein which is produced by β-hemolytic streptococci group A,C and G.It binds to plasminogen(Pg) to form a complex that converts substrate Pg to plasmin.And it can lyse blood clots.We summarized the characteristics、status、research history、catalytic mechanism of it.In addition,Because of its short half-life、bleeding、non fibrin-specific and recurring rate,it is necessary to reconstruct it by gene engineering to obtain better curative effect. |
| |
| Keywords: | streptokinase recombinant streptokinase plasminogen |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
