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Synthesis and biological evaluation of new mannose 6-phosphate analogues |
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| Authors: | Vidal Sébastien Garcia Marcel Montero Jean-Louis Morère Alain |
| Affiliation: | a Laboratoire de Chimie Biomoléculaire (UMR 5032), Université Montpellier II, Ecole Nationale Supérieure de Chimie de Montpellier, 8 Rue de l'Ecole Normale, F-34296, Montpellier Cedex 05, France b INSERM, Unité 540, EMCC, 60 Rue de Navacelles, F-34090, Montpellier, France |
| Abstract: | Three new analogues of mannose 6-phosphate (M6P)—a sulphate and two carboxylates—have been synthesized and their affinity toward the M6P/IGFII receptor evaluated by affinity column chromatography. These compounds display strong binding to the receptor and therefore are new M6P analogues which may find some dermatological applications, for example healing of post-surgical scars. |
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