Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats |
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Authors: | S. Amos E. Kolawole P. Akah C. Wambebe K. Gamaniel |
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Affiliation: | Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria. samsonamos@yahoo.co.uk |
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Abstract: | Behavioral effects of the aqueous extract of Guiera senegalensis on the central nervous system of mice and rats were investigated. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behavior, exploratory activity and performance on treadmills (rota-rod) were evaluated. The results revealed that the aqueous extract of G. senegalensis reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behavior in rats. The extract also decreased exploratory activity in mice and had no observable effects on motor coordination (rota-rod) at the doses tested. The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature. |
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Keywords: | G. senegalensis Gross behavior pentobarbital sleep motor coordination exploratory activity |
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