Immunoreactive alpha-melanotropin and beta-endorphin in the toad pars intermedia: dissociation in storage, secretion and subcellular localization |
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| Authors: | Y P Loh A Li H A Gritsch R L Eskay |
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| Institution: | 1. Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development National Institute of Mental Health, Bethesda, Maryland 20205, USA;1. Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205, USA |
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| Abstract: | Storage, secretion and subcellular localization of immunoreactive α -melanotropin (α -MSHi) and β -endorphin (β -ENDi) were examined in the pars intermedia of toads adapted to a black or white background. During white adaptation, there was a selective increase in storage of α -MSHi but not β -ENDi. Subcellular fractionation and release studies suggest the presence of two pools of peptides in the toad pars intermedia, each containing different molar ratios of α -MSHi and β -ENDi and regulated differently in their release. |
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